ORL

This is a new literature review updated in May 2022. In case some essential information is missing, please contact us at: rafael@hcuge.ch.

Exploring Trajectory Curves from Loss of Smell and Taste in Previously Hospitalized COVID-19 Survivors: the LONG-COVID-EXP-CM Multicenter Study 

Fernández-de-Las-Peñas C, Martín-Guerrero JD, Navarro-Pardo E, Cancela-Cilleruelo I, Moro-López-Menchero P, Pellicer-Valero OJ. J Gen Intern Med. 2022 Feb 22:1–3. doi: 10.1007/s11606-022-07459-8. Epub ahead of print. PMID: 35194745; PMCID: PMC8863099.

In this Spanish study, 1593 participants (45% women, age: 61, SD: 16 years) were assessed at T0 (hospital admission), T1 (mean: 8.4, range 6–10 months), and T2 (mean: 13.2, range 11–15 months) after discharge. The mosaic plots revealed that prevalence of loss of smell decreased from 8.1% (n = 130) at T0, to 4.0% (n = 64) at T1, to 3.1% (n = 49) at T2. Overall, 91% of those patients (n = 119/130) experiencing anosmia at hospitalization (T0) had recovered 7 months after (T1). Further, 82% (53/64) of those with anosmia at T1 had developed it “de novo” (did not experience anosmia at T0). The prevalence of ageusia decreased from 7.1% (n = 114) at T0, to 3.0% (n = 48) at T1, to 1.75% (n = 28) at T2. Again, 90% of individuals (103/114) experiencing ageusia at hospitalization (T0) had recovered 7 months after (T1), whereas 77% (37/48) patients with ageusia at T1 had developed it “de novo.” 

Link to study: Exploring Trajectory Curves from Loss of Smell and Taste in Previously Hospitalized COVID-19 Survivors: the LONG-COVID-EXP-CM Multicenter Study

Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: Results from chemosensitive testing eight months after the acute infection

Hintschich CA, Fischer R, Hummel T, Wenzel JJ, Bohr C, Vielsmeier V.. PLoS One. 2022 Mar 23;17(3):e0265686. doi: 10.1371/journal.pone.0265686. PMID: 35320821; PMCID: PMC8942205.

Link to study: Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: Results from chemosensitive testing eight months after the acute infection

Long-Term Persistence of Olfactory and Gustatory Disorders in COVID-19 Patients 

Nguyen NN, Hoang VT, Dao TL, Meddeb L, Cortaredona S, Lagier JC, Million M, Raoult D, Gautret P. Front Med (Lausanne). 2022 Feb 25;9:794550. doi: 10.3389/fmed.2022.794550. PMID: 35280874; PMCID: PMC8915119.

Link to study: Long-Term Persistence of Olfactory and Gustatory Disorders in COVID-19 Patients