Vaccination

This is a new literature review updated on may 2022. In case some essential information is missing, please contact us at: rafael@hcuge.ch.

Symptoms After COVID-19 Vaccination in Patients with Post-Acute Sequelae of SARS-CoV-2 

Nehme M, Braillard O, Salamun J, Jacquerioz F, Courvoisier DS, Spechbach H, Guessous I. J Gen Intern Med. 2022 Feb 22:1–4. doi: 10.1007/s11606-022-07443-2. Epub ahead of print. PMID: 35194744; PMCID: PMC8863092.

Out of 1596 COVID-19 patients evaluated at the Geneva University Hospitals (47.1% vaccinated: 26.6% one dose, 20.5% two doses), symptoms disappeared (30.8%) or improved (4.7%) in 35.5% of cases following vaccination, were stable in 28.7% of cases, and worsened in 3.3% of cases. Symptoms’ evolution was reported as other in 29.0% of cases and 2.6% preferred not to answer. Symptoms’ improvement or worsening occurred within 5 days post-vaccination in 69.6% and 82.3% of cases respectively. Vaccination (one or two doses) was associated with a decreased prevalence of the six cardinal post-SARS-CoV-2 symptoms (fatigue, difficulty concentrating or memory loss, loss of or change in smell, loss of or change in taste, shortness of breath, and headache); adjusted odds ratio, aOR 0.72; 0.56–0.92. Vaccination with 2 doses was associated with a decreased prevalence of dyspnea (aOR 0.34; 0.14–0.82) and change in taste (0.38; 0.18–0.83) as well as a decreased prevalence of any one symptom (aOR 0.60; 0.43–0.83).

Link to study: Symptoms After COVID-19 Vaccination in Patients with Post-Acute Sequelae of SARS-CoV-2

Post-COVID-19 syndrome and humoral response association after one year in vaccinated and unvaccinated patients 

Peghin M, De Martino M, Palese A, Gerussi V, Bontempo G, Graziano E, Visintini E, Elia D, Dellai F, Marrella F, Fabris M, Curcio F, Sartor A, Isola M, Tascini C. Clin Microbiol Infect. 2022 Mar 23:S1198-743X(22)00155-0. doi: 10.1016/j.cmi.2022.03.016. Epub ahead of print. PMID: 35339673; PMCID: PMC8940723.

Link to study: Post-COVID-19 syndrome and humoral response association after one year in vaccinated and unvaccinated patients